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Tramadol tablets are part of the group of opioid psychotropic analgesics. This drug is very strong. It provides a long-lasting and rapid analgesic effect. Although in its effectiveness, this drug is several times weaker than morphine - the most widely known representative of the narcotic analgesics.
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Description of the mechanism of action
The drug is an opioid analgesic of a synthetic nature, which provides a long-term analgesic effect. This drug directly affects the spinal cord and central nervous system, blocks the conduction of pain impulses, and increases the effect of other sedatives.
Tramadol promotes the activation of opioid receptors in the gastrointestinal tract and in the brain, does not allow catecholamines to break down, and maintains their concentration in the central nervous system. It also initiates the opening of potassium and calcium channels.
Tramadol in therapeutic dosage does not have a pronounced effect on the respiratory system and hemodynamics, does not change the pressure in the pulmonary artery in any way, but is able to slightly slow down intestinal peristalsis. In addition to the fact that the drug has an analgesic effect, it also has a slight sedative (that is, calming) and antitussive effect.
According to experts, the use of Tramadol is very effective. The therapeutic effect occurs within 15-30 minutes after the tablet is taken. And it can last from 6 to 8 hours.
However, this drug is dangerous in that with its long-term use, drug addiction can be provoked.
Indications for use
The drug is intended to relieve moderate to severe pain syndrome. Similar phenomena can be observed in the post-traumatic and postoperative period, occurring with inflammatory and vascular disorders, as well as oncological diseases.
According to the instructions for use and reviews of the drug Tramadol, a specialist can prescribe it before performing a therapeutic or diagnostic procedure on a patient that will be accompanied by serious pain.
Possible contraindications
Judging by the reviews of Tramadol, the use of this drug has some limitations. The drug is contraindicated in the presence of:
- severe renal and hepatic insufficiency;
- pregnancy and breastfeeding;
- age under fourteen years;
- hypersensitivity to the components of the drug;
- conditions accompanied by suppression of the central nervous system and respiratory functions, which include poisoning with certain sleeping pills, psychotropic drugs, or opioid analgesics, as well as alcohol intoxication.
Simultaneous administration of the drug with MAO inhibitors is not allowed, Tramadol can be prescribed only two weeks after stopping their use. This medication should be used with particular caution in the following cases:
- with disorders of consciousness of various origins;
- an attack of intracranial hypertension;
- traumatic brain injury;
- epileptic syndrome and a number of other conditions that are accompanied by loss of self-control and disruption of the respiratory system.
Side effects
Experts also note the manifestation of side effects when the drug is abruptly discontinued after prolonged use, namely sweating, fever, and drowsiness. It is necessary to wait out such negative reactions for 43 hours while withdrawal symptoms are observed. Many people talk about addiction to the drug. If the administration is carried out intramuscularly, then cancer patients develop a craving for a new dose.
A number of specialists note the pointlessness of taking Tramadol if the effect of its use is not noticed. By the way, it is not always achieved and often depends on the dose and individual characteristics of the patient's pathology.